24-week data from the Phase 3 STOP-HS clinical trial program of povorcitinib in patients with hidradenitis suppurativa (HS) selected as a late-breaking oral presentation
Today Incyte (Nasdaq:INCY) announced that it will present new data from its dermatology portfolio at the European Association of Dermatology and Venerology (EADV) 2025 Congress, held from September 17 – 20, in Paris. Highlights include late-breaking, oral and poster presentations featuring data for povorcitinib (INCB054707), an oral small-molecule JAK1 inhibitor, and ruxolitinib cream (Opzelura®), a topical JAK1/2 inhibitor.
“Our presence at EADV demonstrates the significant progress across our dermatology portfolio. The late-breaking data from the STOP-HS clinical trial program reinforce the potential of povorcitinib to benefit patients impacted by hidradenitis suppurativa (HS), a challenging and debilitating immune-mediated dermatologic condition,” said Pablo J. Cagnoni, M.D., President and Head of Research and Development, Incyte. “Data on ruxolitinib cream in new patient populations continues to demonstrate safety and efficacy in individuals with atopic dermatitis (AD), vitiligo and prurigo nodularis (PN). We look forward to advancing these studies, and to providing additional treatment options for patients.”
Key abstracts from Incyte-sponsored programs include:
Late-Breaking Oral Presentations
Hidradenitis Suppurativa
Povorcitinib for Moderate to Severe Hidradenitis Suppurativa: Week 24 Interim Phase 3 Results
Presentation ID: D1T01.1C. Session Title: Late Breaking News. Presentation Time: 8:15 – 9:00 a.m. ET (2:15 – 3:00 p.m. CEST), September 17, 2025
Prurigo Nodularis
Efficacy and Safety of Ruxolitinib Cream in Patients With Prurigo Nodularis: Pooled Results From the Phase 3 TRuE-PN1 and TRuE-PN2 Randomized, Vehicle-Controlled Studies
Presentation ID: D1T01.2A. Session Title: Late Breaking News. Presentation Time: 10:00 – 10:15 a.m. ET (4:00 – 4:15 p.m. CEST), September 17, 2025
Oral Presentation
Vitiligo
Prevalence and Clinical Characteristics of Vitiligo-Associated Hearing Loss Among Patients Enrolled in a Phase 2 Clinical Trial of Povorcitinib
Presentation ID: FC03.1G. Session Title: Pigmentary Disorders. Presentation Time: 9:15 – 10:45 a.m. ET (3:15 – 4:45 p.m. CEST), September 18, 2025
Poster Presentations
Atopic Dermatitis
Ruxolitinib Cream Demonstrated Long-Term Disease Control with Time Off Treatment in Children with Atopic Dermatitis
Poster #3193
Vitiligo
Characterization of Vitiligo and Repigmentation Response by Lesion Extent and Distribution: Subgroup Analyses from the Ruxolitinib Cream Phase 2 TRuE-V Mechanism of Action Study
Poster #2741
An Open-Label, Phase 2, Safety and Efficacy Study of Ruxolitinib Cream in Patients With Genital Vitiligo
Poster #3236
Efficacy and Safety of Ruxolitinib Cream Combined With NB-UVB Phototherapy for Treatment of Vitiligo
Poster #2738
Multiple Indications
Long-Term Safety of Ruxolitinib Cream in Pediatric and Adult Patients: An Analysis of 7 Phase 3 Clinical Trials in Atopic Dermatitis and Nonsegmental Vitiligo
Poster #2653
